Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
Cell Res. 2014 Jun;24(6):649-50. doi: 10.1038/cr.2014.50. Epub 2014 Apr 15.
Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors.
调控信息储存在修饰组蛋白中,由效应蛋白(“读取器”)进行功能翻译,这些蛋白识别组蛋白标记以确定反应的特异性。最近的一项研究确定肿瘤抑制蛋白 ZMYND11 为甲基化组蛋白变体 H3.3 的唯一读取器,这揭示了转录调控在抑制肿瘤中的作用。