识别甲基化组蛋白变体 H3.3 以预防肿瘤。
Recognizing methylated histone variant H3.3 to prevent tumors.
机构信息
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
出版信息
Cell Res. 2014 Jun;24(6):649-50. doi: 10.1038/cr.2014.50. Epub 2014 Apr 15.
Abstract
Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors.
摘要
调控信息储存在修饰组蛋白中，由效应蛋白（“读取器”）进行功能翻译，这些蛋白识别组蛋白标记以确定反应的特异性。最近的一项研究确定肿瘤抑制蛋白 ZMYND11 为甲基化组蛋白变体 H3.3 的唯一读取器，这揭示了转录调控在抑制肿瘤中的作用。
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