Maruyama M, Kitamura M, Arai K, Yoshikawa T, Kosaki G, Takizawa T, Koike M
Div. of Surgery, Tokyo Metropolitan Komagome Hospital.
Gan No Rinsho. 1989 Jul;35(8):905-11.
We have studied the clinico-pathological features of 42 autopsied cases involving solid, poorly differentiated carcinomas that histologically revealed a medullary growth pattern but none showing a tubular formation. Ninety percent of these 42 cases were male, and the 42 carcinomas were of 5 histological types as listed below: 1) small cell carcinoma-atypical carcinoid type (15 cases); 2) AFP-producing type (so-called "hepatoid carcinoma") (4 cases); 3) acinar type (8 cases); 4) signet ring cell-medullary type (2 cases); and, 5) large cell type (13 cases) The small cell carcinoma-atypical carcinoid type, the AFP-producing type, and the large cell type showed a severe hematogenous metastasis. In contrast, the acinar type had a lymphogenous metastasis the signet ring cell-medullary type, showed a lymphogenous and peritoneal metastasis. Each histological type well corresponded to the typical biological characteristics of each of these carcinomas of the stomach.
我们研究了42例尸检病例的临床病理特征，这些病例均为实性低分化癌，组织学显示为髓样生长模式，但均无管状结构形成。这42例病例中90%为男性，42例癌分为以下5种组织学类型：1）小细胞癌-非典型类癌型（15例）；2）甲胎蛋白产生型（所谓“肝样癌”）（4例）；3）腺泡型（8例）；4）印戒细胞-髓样型（2例）；5）大细胞型（13例）。小细胞癌-非典型类癌型、甲胎蛋白产生型和大细胞型表现出严重的血行转移。相比之下，腺泡型有淋巴转移，印戒细胞-髓样型表现为淋巴转移和腹膜转移。每种组织学类型与这些胃癌各自典型的生物学特征高度相符。
