Koseki C, Imai M, Hirata Y, Yanagisawa M, Masaki T
Department of Pharmacology, National Cardiovascular Center Research Institute, Osaka, Japan.
J Cardiovasc Pharmacol. 1989;13 Suppl 5:S153-4. doi: 10.1097/00005344-198900135-00040.
By tissue autoradiography in the rat, we demonstrated that receptors for endothelin-1 (ET-1) were distributed not only in the cardiovascular system but also in the noncardiovascular organs including the brain, lung, intestine, etc. In the brain, the receptors were mainly found in the basal ganglia and brainstem, in which nuclei are known to be cardiovascular regulatory sites. In addition to its direct vasoconstricting action, ET-1 may exert neural cardiovascular control as a neuropeptide.
通过对大鼠进行组织放射自显影，我们证明内皮素-1（ET-1）受体不仅分布于心血管系统，还分布于包括脑、肺、肠等在内的非心血管器官。在脑中，受体主要发现于基底神经节和脑干，已知这些核团是心血管调节部位。除了其直接的血管收缩作用外，ET-1可能作为一种神经肽发挥神经心血管控制作用。
