Castelino Sheena, Miah Hamida, Auyeung Vivian, Vogt Florian
Guy's and St. Thomas' NHS Foundation Trust, St. Thomas' Hospital, London, UK
King's College London, Institute of Pharmaceutical Sciences, London, UK.
Int J STD AIDS. 2015 Feb;26(2):93-7. doi: 10.1177/0956462414530887. Epub 2014 Apr 14.
The aim of this study was to evaluate whether the change in the mode of supply of HIV medicines to a homecare model was associated with any change in adherence and patient outcomes. We conducted a retrospective analysis of medical records of 100 patients who received supplies from a clinic-based hospital HIV pharmacy and 100 patients who were started on home delivery over a three-month period and were followed up over six months. Data on patient demographics, type of HIV drug regimen, HIV viral load, CD4% and adherence status were analysed. The mode of delivery had no significant effect on CD4% (p > 0.05), HIV viral load status (p > 0.05) or adherence status (p > 0.05). There was a significant increase in CD4% over time for both groups (p < 0.01). This study suggests that expanding home delivery as a model of care in London HIV clinics is safe and does not affect adherence and patient outcomes as indicated by HIV viral load and CD4%.
本研究的目的是评估将艾滋病毒药物供应模式转变为居家护理模式是否与依从性和患者预后的任何变化相关。我们对100名从一家以诊所为基础的医院艾滋病毒药房领取药物的患者以及100名在三个月内开始接受上门送药服务并随访六个月的患者的病历进行了回顾性分析。分析了患者人口统计学数据、艾滋病毒药物治疗方案类型、艾滋病毒病毒载量、CD4%以及依从性状况。送药模式对CD4%（p＞0.05）、艾滋病毒病毒载量状况（p＞0.05）或依从性状况（p＞0.05）均无显著影响。两组的CD4%均随时间显著增加（p＜0.01）。本研究表明，在伦敦艾滋病毒诊所将上门送药作为一种护理模式进行推广是安全的，并且不会像艾滋病毒病毒载量和CD4%所显示的那样影响依从性和患者预后。
