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V型成骨不全症中腓骨非创伤性肥厚性骨痂酷似骨肉瘤:一例报告

Non-traumatic hypertrophic callus of the fibula mimicking osteosarcoma in osteogenesis imperfecta type V: a case report.

作者信息

Radu Arnold, Kanza Rene Epunza, Barabas Dezso, Lessard Michel, Berube Michel

机构信息

Department of Radiology, McGill University Health Center (MUHC), Montreal, QC, H3G 1Y6, Canada.

出版信息

Skeletal Radiol. 2014 Sep;43(9):1333-6. doi: 10.1007/s00256-014-1884-8. Epub 2014 Apr 15.

DOI:10.1007/s00256-014-1884-8
PMID:24733362
Abstract

We report a case of hyperplastic callus mimicking osteosarcoma in the fibula of a patient with osteogenesis imperfecta type V. Among the various imaging modalities, computed tomography was the most useful in distinguishing this rare process from a malignant entity. In addition, simple radiographs demonstrated the presence of characteristic "zebra lines", a manifestation of cyclic bisphosphonate therapy during childhood.

摘要

我们报告了一例患有V型成骨不全症患者腓骨中出现类似骨肉瘤的增生性骨痂病例。在各种成像方式中,计算机断层扫描对于区分这种罕见病变与恶性实体最为有用。此外,简单的X线片显示出特征性的“斑马线”,这是儿童期接受双膦酸盐循环治疗的一种表现。

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Skeletal Radiol. 2014 Sep;43(9):1333-6. doi: 10.1007/s00256-014-1884-8. Epub 2014 Apr 15.
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本文引用的文献

1
Osteogenesis imperfecta type V: marked phenotypic variability despite the presence of the IFITM5 c.-14C>T mutation in all patients.成骨不全症 V 型:所有患者均存在 IFITM5 c.-14C>T 突变,但表型变异显著。
J Med Genet. 2013 Jan;50(1):21-4. doi: 10.1136/jmedgenet-2012-101307.
2
A Remarkable Case of Diffuse Cancellous Osteoma of the Femur, following a Fracture, in which similar growths afterwards developed in connection with other bones.一例股骨骨折后弥漫性松质骨骨瘤的罕见病例,随后在其他骨骼上也出现了类似的生长。
Proc R Soc Med. 1908;1(Pathol Sect):83-115. doi: 10.1177/003591570800101007.
3
Zebra lines of pamidronate therapy in children.
儿童帕米膦酸盐治疗的斑马纹
J Bone Joint Surg Am. 2007 Jul;89(7):1511-6. doi: 10.2106/JBJS.F.00726.
4
Hyperplastic callus formation in osteogenesis imperfecta type V mimicking osteosarcoma: 4-year follow-up with resolution.V型成骨不全症中类似骨肉瘤的增生性骨痂形成:4年随访及病情缓解
Skeletal Radiol. 2006 Jun;35(6):402-5. doi: 10.1007/s00256-005-0039-3. Epub 2005 Nov 25.
5
Osteogenesis imperfecta.成骨不全症
Lancet. 2004 Apr 24;363(9418):1377-85. doi: 10.1016/S0140-6736(04)16051-0.
6
Hyperplastic callus formation in osteogenesis imperfecta.成骨不全症中的增生性骨痂形成。
Ann Diagn Pathol. 2003 Aug;7(4):231-5. doi: 10.1016/s1092-9134(03)00051-0.
7
Osteogenesis imperfecta and hyperplastic callus formation in a family: a report of three cases and a review of the literature.一个家族中的成骨不全与增生性骨痂形成:三例报告并文献复习
J Pediatr Orthop B. 2003 Mar;12(2):88-96. doi: 10.1097/01.bpb.0000043724.21564.32.
8
Type V osteogenesis imperfecta: a new form of brittle bone disease.V型成骨不全症:一种新型脆性骨病。
J Bone Miner Res. 2000 Sep;15(9):1650-8. doi: 10.1359/jbmr.2000.15.9.1650.
9
MRI and CT features of hyperplastic callus in osteogenesis imperfecta tarda.迟发性成骨不全中增生性骨痂的MRI和CT特征
Eur Radiol. 1999;9(4):665-8. doi: 10.1007/s003300050729.
10
Hyperplastic callus formation in osteogenesis imperfecta: CT and MRI findings.成骨不全中增生性骨痂形成:CT和MRI表现
Eur Radiol. 1998;8(7):1137-9. doi: 10.1007/s003300050521.