Yoshida K, Kawano Y, Hirata Y, Kawamura M, Kuramochi M, Omae T
Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan.
J Cardiovasc Pharmacol. 1989;13 Suppl 6:S24-6.
We examined the effects of intracerebroventricular (i.c.v.) administration of atrial natriuretic factor (ANF) on pressor and natriuretic responses induced by i.c.v. angiotensin II (Ang II) or hypertonic NaCl in conscious male Wistar rats. The i.c.v. artificial cerebrospinal fluid (CSF) or ANF alone did not cause recognizable changes in mean blood pressure (MBP), urinary volume (UV), or sodium excretion (UNaV). The i.c.v. Ang II or 0.6 M NaCl raised MBP, decreased UV, and increased UNaV. When ANF was administered with Ang II, the Ang II-induced changes in MBP, UV, and UNaV were diminished significantly. ANF also opposed the effects of 0.6 m NaCl, though the effect was significant only in the case of blood pressure. Our results indicate that brain ANF may have antipressor and anti-natriuretic roles.
我们研究了在清醒雄性Wistar大鼠中，脑室内（i.c.v.）注射心房利钠因子（ANF）对脑室内注射血管紧张素II（Ang II）或高渗氯化钠（NaCl）诱导的升压和利钠反应的影响。单独脑室内注射人工脑脊液（CSF）或ANF不会引起平均血压（MBP）、尿量（UV）或钠排泄量（UNaV）的明显变化。脑室内注射Ang II或0.6 M NaCl会升高MBP、降低UV并增加UNaV。当ANF与Ang II一起给药时，Ang II诱导的MBP、UV和UNaV变化显著减弱。ANF也能对抗0.6 m NaCl的作用，尽管仅在血压方面作用显著。我们的结果表明，脑内ANF可能具有抗升压和抗利钠作用。
