多药外排泵在淋病奈瑟菌临床多重耐药菌株抗菌耐药特性中的重要性。
Importance of multidrug efflux pumps in the antimicrobial resistance property of clinical multidrug-resistant isolates of Neisseria gonorrhoeae.
作者信息
Golparian Daniel, Shafer William M, Ohnishi Makoto, Unemo Magnus
机构信息
WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections (STIs), National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center, Decatur, Georgia, USA.
出版信息
Antimicrob Agents Chemother. 2014 Jun;58(6):3556-9. doi: 10.1128/AAC.00038-14. Epub 2014 Apr 14.
Abstract
The contribution of drug efflux pumps in clinical isolates of Neisseria gonorrhoeae that express extensively drug-resistant or multidrug-resistant phenotypes has heretofore not been examined. Accordingly, we assessed the effect on antimicrobial resistance of loss of the three gonococcal efflux pumps associated with a known capacity to export antimicrobials (MtrC-MtrD-MtrE, MacA-MacB, and NorM) in such clinical isolates. We report that the MIC of several antimicrobials, including seven previously and currently recommended for treatment was significantly impacted.
摘要
此前尚未研究药物外排泵在表达广泛耐药或多重耐药表型的淋病奈瑟菌临床分离株中的作用。因此，我们评估了在这类临床分离株中，与已知抗菌药物外排能力相关的三种淋病奈瑟菌外排泵（MtrC-MtrD-MtrE、MacA-MacB和NorM）缺失对抗菌药物耐药性的影响。我们报告称，包括七种之前和目前推荐用于治疗的抗菌药物在内，几种抗菌药物的最低抑菌浓度受到了显著影响。
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