Yahagi Eiichiro, Mabuchi Tomotaka, Nuruki Hiroko, Manabe Yasuaki, Ikoma Norihiro, Ozawa Akira, Yamamoto Naoyuki, Tanaka Eitaro, Sekido Yasutomo, Matsuyama Takashi
Department of Dermatology, Tokai University Hachioji Hospital, 1838 Ishikawamachi, Hachioji, Tokyo 192-0032, Japan.
Tokai J Exp Clin Med. 2014 Mar 20;39(1):5-9.
A 73-year-old male with diabetes mellitus had been treated with insulin for six years. He developed a solid mass on his left lateral of the abdomen at the insulin injection site. A firm subcutaneous mass with dark-red erythema was overlaid by dark-brown keratinized plaques. On histological examination of the mass, keratin proliferation and epidermal papilloma were observed. There were four previously reported cases of acanthosis nigricans that were considered to be caused by continuous injections of insulin. Using immunohistochemistry, in our case the findings were positive in the basal epithelial and prickle cell layers when the patient's lesion was dyed with insulin-like growth factor (IGF)-1 antibody. The coexistence of dermal IGF-1 receptor and acanthosis nigricans found in our patient has not been reported previously, to our knowledge.
一名73岁的男性糖尿病患者已接受胰岛素治疗六年。他在胰岛素注射部位的左腹部外侧出现了一个实性肿块。一个坚实的皮下肿块，伴有暗红色红斑，上面覆盖着深褐色角化斑块。对该肿块进行组织学检查时，观察到角质增生和表皮乳头瘤。此前有四例黑棘皮病病例被认为是由持续注射胰岛素引起的。通过免疫组织化学方法，在我们的病例中，当用胰岛素样生长因子（IGF）-1抗体对患者病变进行染色时，在基底上皮层和棘细胞层发现结果呈阳性。据我们所知，我们患者中发现的真皮IGF-1受体与黑棘皮病并存的情况此前尚未见报道。
