肝硬化中的C反应蛋白与细菌感染
C-reactive protein and bacterial infection in cirrhosis.
作者信息
Pieri Giulia, Agarwal Banwari, Burroughs Andrew K
机构信息
The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hamsptead NHS Trust and Institute of Liver and Digestive Health, University College London (Giulia Pieri, Andrew K. Burroughs).
Critical Care Medicine, Royal Free London NHS Foundation Trust (Agarwal Banwari), London, United Kingdom.
出版信息
Ann Gastroenterol. 2014;27(2):113-120.
Abstract
In the general population, C-reactive protein (CRP) level increases in the presence of acute or chronic inflammation and infections. In patients with cirrhosis, the basal level is higher than in patients without cirrhosis, due to chronic hepatic and other inflammation, but when infection occurs the more severe the underlying liver dysfunction, the lower the increase in CRP. Therefore, the predictive power of CRP for infection and prognosis is weak in patients with decompensated/advanced cirrhosis and in the intensive care setting. However, higher CRP and also persistently elevated CRP levels can help identify patients with a higher short-term risk of mortality.
摘要
在普通人群中，急性或慢性炎症及感染时C反应蛋白（CRP）水平会升高。肝硬化患者由于慢性肝脏及其他炎症，其基础水平高于无肝硬化的患者，但发生感染时，潜在肝功能障碍越严重，CRP升高幅度越低。因此，在失代偿期/晚期肝硬化患者及重症监护环境中，CRP对感染及预后的预测能力较弱。然而，较高的CRP水平以及持续升高的CRP水平有助于识别短期死亡风险较高的患者。
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