Xavier Samuel P, Dias Rafael R, Sehn Felipe P, Kahn Adrian, Chaushu Liat, Chaushu Gavriel
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Tel Aviv University, Tel Aviv, Israel.
Clin Oral Implants Res. 2015 Sep;26(9):1080-5. doi: 10.1111/clr.12404. Epub 2014 Apr 16.
Surgical techniques as sinus floor augmentation have made it possible to increase the bone volume of the posterior maxilla so that implant placement may be feasible. A large variety of bone grafting materials have been utilized for sinus floor augmentation. A good alternative is allograft. Fresh frozen bone is harvested from live or cadaveric donors and then immediately frozen and stored at -80 °C. To date, studies about the effect of fresh frozen bone are scarce.
Evaluation of new bone formation, following maxillary sinus grafting with autograft vs. fresh frozen allograft.
A split-mouth edentulous design including 15 patients was used. Sinus floor augmentation was carried out using either autogenous bone harvested from the ramus area or fresh frozen bone from allogeneic femoral heads. The choice was determined randomly, using a randomized table. The grafted sinus was left to heal for 6 months. Biopsies were harvested from the lateral wall. The biopsies were used for bone histology and histomorphometric analysis. After collection of the biopsy, dental implants were placed. After a healing period of 6 months, the implants were loaded.
Implant survival, histology, and histomorphometry of sinuses grafted with autogenous or fresh frozen bone were similar. The new bone formation took place predominantly around and in-between particles.
The findings of the present study support the use of fresh frozen bone allografts for sinus floor augmentation.
诸如上颌窦底提升术等外科技术使得增加上颌后部的骨量成为可能，从而使种植体植入成为可行。多种骨移植材料已被用于上颌窦底提升术。同种异体骨是一种很好的替代材料。新鲜冷冻骨从活体或尸体供体获取，然后立即冷冻并储存在-80°C。迄今为止，关于新鲜冷冻骨效果的研究很少。
评估自体骨与新鲜冷冻同种异体骨在上颌窦移植后的新骨形成情况。
采用包括15例患者的分口无牙设计。上颌窦底提升术使用从下颌升支区域获取的自体骨或来自异体股骨头的新鲜冷冻骨进行。选择通过随机表随机确定。移植的上颌窦让其愈合6个月。从侧壁获取活检组织。活检组织用于骨组织学和组织形态计量分析。活检组织采集后植入牙种植体。经过6个月的愈合期后，对种植体进行加载。
自体骨或新鲜冷冻骨移植的上颌窦的种植体存活率、组织学和组织形态计量学相似。新骨形成主要发生在颗粒周围和颗粒之间。
本研究结果支持使用新鲜冷冻同种异体骨进行上颌窦底提升术。
