Department of Pediatrics, Juliana Children's Hospital/HAGA Teaching Hospital, Sportlaan 600, 2566 MJ The Hague, The Netherlands.
Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands; Hepcidinanalysis.com, Geert Grooteplein 10 (830), 6525 GA Nijmegen, The Netherlands.
J Cyst Fibros. 2014 Dec;13(6):639-44. doi: 10.1016/j.jcf.2014.03.007. Epub 2014 Apr 13.
The value of ferritin in the diagnosis of iron deficiency is limited in patients with CF since it increases in the presence of inflammation. We hypothesized that the soluble transferrin receptor (sTfR) and hepcidin may provide more information than ferritin in assessing iron status in children with CF.
We analyzed sTfR and hepcidin in relation to conventional iron status indicators in 49 children with CF.
We found no differences in sTfR concentration between children with and those without ID. sTfR concentrations were within the normal range in all children. Hepcidin concentrations were low, and concentrations below the limit of detection were observed in 25% of the clinically stable children.
The sTfR is not useful to determine the iron status in this population, whereas hepcidin might serve as an early indicator of deficient iron stores in children with CF.
铁蛋白在 CF 患者缺铁的诊断中的价值有限，因为它在炎症存在时会增加。我们假设可溶性转铁蛋白受体 (sTfR) 和铁调素可能比铁蛋白提供更多有关 CF 患儿铁状态的信息。
我们分析了 49 例 CF 患儿的 sTfR 和铁调素与常规铁状态指标的关系。
我们发现 ID 患儿与非 ID 患儿的 sTfR 浓度无差异。所有患儿的 sTfR 浓度均在正常范围内。铁调素浓度较低，25%的临床稳定患儿的浓度低于检测限。
sTfR 对于确定该人群的铁状态没有帮助，而铁调素可能是 CF 患儿铁储存不足的早期指标。
