斯普拉格-道利大鼠出生后早期暴露于缺氧环境下的听力结果。
Hearing outcome of early postnatal exposure to hypoxia in Sprague-Dawley rats.
作者信息
Daniel S J, McIntosh M, Akinpelu O V, Rohlicek C V
机构信息
Department of Otolaryngology - Head and Neck Surgery, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.
McGill Auditory Sciences Laboratory, Montreal Children's Hospital - McGill University Health Centre, Quebec, Canada.
出版信息
J Laryngol Otol. 2014 Apr;128(4):331-335. doi: 10.1017/S002221511300265X.
OBJECTIVE
To determine the effect of experimentally induced hypoxia, in the first 10 days of life, on physiological hearing in a Sprague-Dawley rat model.
METHODS
A prospective, controlled animal study was carried out using 22 male rat pups. The rats in the hypoxic group ( = 12) were reared in hypoxia for the first 10 days of life, and subsequently reared in normoxia, while those in the control group ( = 10) were reared in normoxia for the duration of the experiment. Hearing was assessed using auditory brainstem response testing at approximately 72 days of age.
RESULTS
The hypoxia group had higher auditory brainstem response thresholds for all frequencies tested (more pronounced at 16 kHz), compared with controls. Wave I-V inter-peak latencies were more prolonged in the hypoxic rats, while both groups had similar wave I latencies.
CONCLUSION
Chronic postnatal hypoxia induced permanent hearing loss in this Sprague-Dawley rat model. Prolonged wave I-V inter-peak latencies suggested functional abnormality in the central auditory pathway.
目的
确定出生后前10天实验性诱导的低氧对Sprague-Dawley大鼠模型生理听力的影响。
方法
使用22只雄性幼鼠进行了一项前瞻性对照动物研究。低氧组（n = 12）的大鼠在出生后的前10天饲养于低氧环境中，随后饲养于常氧环境中，而对照组（n = 10）的大鼠在实验期间一直饲养于常氧环境中。在大约72日龄时使用听性脑干反应测试评估听力。
结果
与对照组相比，低氧组在所有测试频率下的听性脑干反应阈值更高（在16kHz时更明显）。低氧大鼠的波I-V峰间期延长，而两组的波I潜伏期相似。
结论
出生后慢性低氧在该Sprague-Dawley大鼠模型中诱导了永久性听力损失。波I-V峰间期延长提示中枢听觉通路存在功能异常。
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