Siegel G, Schnalke F, Stock G, Grote J
Institute of Physiology, Free University of Berlin, Germany.
Adv Prostaglandin Thromboxane Leukot Res. 1989;19:267-70.
In arterial smooth muscle with normal tone or predepolarized and precontracted by noradrenaline, prostacyclin (10(-9) to 10(-6) M) effects a dose-dependent hyperpolarization and relaxation. The hyperpolarization is due to K+ channel opening. In hypoxic vasodilatation, which is likewise induced by membrane hyperpolarization, a share of 20% falls to prostacyclin and 80% to an endothelium derived hyperpolarizing factor.
在具有正常张力或已被去甲肾上腺素预去极化和预收缩的动脉平滑肌中，前列环素（10⁻⁹至10⁻⁶M）可产生剂量依赖性的超极化和舒张作用。这种超极化是由于钾离子通道开放所致。在同样由膜超极化引起的缺氧性血管舒张中，20%归因于前列环素，80%归因于一种内皮源性超极化因子。
