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补体片段C5a去精氨酸对心脏和肾脏的作用部分是由组胺和花生四烯酸代谢产物的释放介导的。

The cardiac and renal effects of the complement fragment C5a des Arg are partly mediated by the release of histamine and arachidonic acid metabolites.

作者信息

Ghanem N S, Abdullah N A, Assem E S

机构信息

Department of Pharmacology, University College London, UK.

出版信息

Agents Actions. 1989 Apr;27(1-2):138-41. doi: 10.1007/BF02222221.

DOI:10.1007/BF02222221
PMID:2473617
Abstract

This report suggests that the release of various inflammatory mediators such as histamine, LTC4, D4 and E4, and TXA2 measured as the stable metabolite TXB2 are partly responsible for the various cardiac and renal effects of the complement fragment C5a des Arg anaphylatoxin, in addition to its direct vasoconstrictor activity.

摘要

本报告表明，补体片段C5a去精氨酸过敏毒素除具有直接血管收缩活性外，其引起的各种心脏和肾脏效应部分归因于组胺、白三烯C4、D4和E4以及作为稳定代谢产物血栓素B2测定的血栓素A2等多种炎症介质的释放。

相似文献

1
The cardiac and renal effects of the complement fragment C5a des Arg are partly mediated by the release of histamine and arachidonic acid metabolites.补体片段C5a去精氨酸对心脏和肾脏的作用部分是由组胺和花生四烯酸代谢产物的释放介导的。
Agents Actions. 1989 Apr;27(1-2):138-41. doi: 10.1007/BF02222221.
2
Anaphylatoxin-induced release of histamine from in vitro perfused guinea pig kidney.过敏毒素诱导豚鼠离体灌注肾脏释放组胺。
Agents Actions. 1988 Apr;23(3-4):181-4. doi: 10.1007/BF02142534.
3
C5a/C5ades-Arg-induced increase in blood pressure in the guinea pig: role of thromboxane.C5a/C5ades-Arg诱导豚鼠血压升高：血栓素的作用
Immunopharmacology. 1990 Jan-Feb;19(1):59-68. doi: 10.1016/0162-3109(90)90027-c.
4
Role of histamine in the spasmogenic effect of the complement peptides C3a and C5a-desArg (classical anaphylatoxin).组胺在补体肽C3a和C5a-去精氨酸（经典过敏毒素）致痉挛作用中的作用
Agents Actions. 1982 Apr;12(1-2):118-21. doi: 10.1007/BF01965121.
5
Identification of classical anaphylatoxin as the des-Arg form of the C5a molecule: evidence of a modulator role for the oligosaccharide unit in human des-Arg74-C5a.经典过敏毒素鉴定为C5a分子的去精氨酸形式：人去精氨酸74-C5a中寡糖单元调节作用的证据。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1833-7. doi: 10.1073/pnas.78.3.1833.
6
Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors.C5adesArg过敏毒素对豚鼠肺实质条的致痉挛活性：白三烯介导成分对环氧化酶抑制剂的敏感性
Biochem Biophys Res Commun. 1984 Dec 28;125(3):852-8. doi: 10.1016/0006-291x(84)91361-5.
7
Amino-acid sequence and disulfide linkages of the anaphylatoxin, des-Arg omega-C5a, from porcine serum.猪血清中过敏毒素去精氨酸ω-C5a的氨基酸序列和二硫键
Hoppe Seylers Z Physiol Chem. 1984 Feb;365(2):151-8. doi: 10.1515/bchm2.1984.365.1.151.
8
Airway responses in vitro following C5a des Arg-induced hyper-responsiveness in vivo in rabbits.在兔体内C5a去精氨酸诱导高反应性后，体外气道反应。
Clin Exp Pharmacol Physiol. 1987 Jan;14(1):7-14. doi: 10.1111/j.1440-1681.1987.tb00951.x.
9
Analysis of the interaction of human C5a and C5a des Arg with human monocytes and neutrophils: flow cytometric and chemotaxis studies.人C5a和C5a去精氨酸产物与人单核细胞和中性粒细胞相互作用的分析：流式细胞术和趋化性研究
J Invest Dermatol. 1989 Feb;92(2):184-9. doi: 10.1111/1523-1747.ep12276710.
10
Leucocytes activated by C5a des Arg promote endothelial prostacyclin (PGI2) production via release of oxygen species in vitro.C5a去精氨酸激活的白细胞通过在体外释放氧物种来促进内皮前列环素（PGI2）的产生。
Agents Actions. 1985 Mar;16(1-2):21-2. doi: 10.1007/BF01999632.

本文引用的文献

1
Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig.乙酰甘油醚磷酸胆碱（AGEPC）。豚鼠心脏过敏反应的一种假定介质。
Circ Res. 1984 Feb;54(2):117-24. doi: 10.1161/01.res.54.2.117.
2
Release of leukotrienes from guinea pig lung stimulated by C5ades Arg anaphylatoxin.C5ades Arg过敏毒素刺激豚鼠肺释放白三烯。
J Immunol. 1982 May;128(5):2247-52.
3
The heart in anaphylaxis.过敏反应中的心脏。
J Allergy Clin Immunol. 1986 May;77(5):663-6. doi: 10.1016/0091-6749(86)90405-7.
4
Granulocyte adherence changes: an index of biocompatibility.粒细胞黏附变化：生物相容性指标。
Kidney Int Suppl. 1988 Mar;24:S68-72.
5
Cardiac dysfunction caused by purified human C3a anaphylatoxin.纯化的人C3a过敏毒素引起的心脏功能障碍。
Proc Natl Acad Sci U S A. 1985 Feb;82(3):886-90. doi: 10.1073/pnas.82.3.886.
6
Anaphylatoxin-induced release of histamine from in vitro perfused guinea pig kidney.过敏毒素诱导豚鼠离体灌注肾脏释放组胺。
Agents Actions. 1988 Apr;23(3-4):181-4. doi: 10.1007/BF02142534.
7
Comparison of the release of various mediators from atrial and ventricular tissues of sensitized guinea-pig hearts.致敏豚鼠心脏心房和心室组织中各种介质释放的比较。
Agents Actions. 1987 Apr;20(3-4):284-7. doi: 10.1007/BF02074692.
8
Renal histamine: release by immune stimuli.肾脏组胺：由免疫刺激释放。
Agents Actions. 1986 Nov;19(3-4):141-9. doi: 10.1007/BF01966198.
9
Cardiac anaphylaxis: the role of different mediators. Part I: Histamine.心脏过敏反应：不同介质的作用。第一部分：组胺。
Allergol Immunopathol (Madr). 1985 May-Jun;13(3):259-72.