Peachell P T, Pearce F L
Department of Chemistry, University College London, UK.
Agents Actions. 1989 Apr;27(1-2):62-4. doi: 10.1007/BF02222199.
Peritoneal mast cells from specific pathogen-free rats that had been sensitized to the nematode Nippostrongylus brasiliensis released histamine in a dose-dependent fashion on challenge with antigen, anti-rat IgE, anti-rat IgG and concanavalin A. Cells from non-sensitized animals showed weak or insignificant responses to these agents. However, the two preparations did not obviously differ in their reactivity to a range of pharmacological agents including ATP, dextran, polyamines and calcium ionophores. Both populations were refractory to cholinergic stimulation. These results show that active sensitization does not per se lead to a global increase in mast cell reactivity or releasability.
来自无特定病原体大鼠的腹膜肥大细胞，这些大鼠已对线虫巴西日圆线虫致敏，在用抗原、抗大鼠IgE、抗大鼠IgG和伴刀豆球蛋白A刺激时，会以剂量依赖的方式释放组胺。来自未致敏动物的细胞对这些试剂的反应较弱或不明显。然而，这两种制剂对一系列药理试剂（包括ATP、葡聚糖、多胺和钙离子载体）的反应性没有明显差异。这两种细胞群对胆碱能刺激均无反应。这些结果表明，主动致敏本身不会导致肥大细胞反应性或释放能力的全面增加。
