结节性博来霉素毒性。

Nodular bleomycin toxicity.

作者信息

Cohen M B, Austin J H, Smith-Vaniz A, Lutzky J, Grimes M M

机构信息

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

出版信息

Am J Clin Pathol. 1989 Jul;92(1):101-4. doi: 10.1093/ajcp/92.1.101.

DOI:10.1093/ajcp/92.1.101

PMID:2473646

Abstract

Pulmonary interstitial fibrosis, a well-known toxic effect of bleomycin therapy, usually presents radiographically as diffuse reticularity. The authors report an unusual case of biopsy-proven bleomycin toxicity that presented as pulmonary nodules mimicking metastatic tumor. The histologic findings resembled those seen in the diffuse form of toxicity but notably also included foci of bronchiolitis obliterans.

摘要

肺间质纤维化是博来霉素治疗众所周知的毒性作用，通常在影像学上表现为弥漫性网状改变。作者报告了一例经活检证实的博来霉素毒性的罕见病例，其表现为类似转移性肿瘤的肺结节。组织学表现类似于弥漫性毒性所见，但值得注意的是，其中也包括闭塞性细支气管炎灶。