Pozzi E, Zanon P
Int J Clin Pharmacol Biopharm. 1978 Dec;16(12):575-8.
Bleomycin is potentially capable of inducing a diffuse interstitial fibrosis of the lung, the pathogenesis of which has not yet been elucidated. The authors have demonstrated that after 48 hr of acute treatment, morphological and functional modifications could be seen in type II pneumocytes, which are responsible for surfactant production. This might be the earliest stage of pulmonary damage.
博来霉素有可能诱发肺部弥漫性间质纤维化，其发病机制尚未阐明。作者已证明，急性治疗48小时后，可在负责表面活性剂产生的II型肺细胞中观察到形态和功能的改变。这可能是肺损伤的最早阶段。
