Ulrich R, Buck B, Distl O, Wohlsein P
Dr. med. vet. Reiner Ulrich, Ph.D., Institut für Pathologie, Tierärztliche Hochschule Hannover, Bünteweg 17, 30559 Hannover, E-Mail:
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2014;42(2):100-5.
Tumours with skeletal-muscle differentiation are rare in companion animals. They are differentiated into benign rhabdomyomas and malignant rhabdomyosarcomas. A female German Holstein calf displayed a congenital, spherical, subcutaneous mass at the lateral side of the head. Histology revealed an encapsulated, expansile, highly cellular mass consisting of a reticular meshwork of moderately pleomorphic, small spindle-shaped to round cells within a fibrovascular to myxoid stroma as well as multifocal, large, blunt, multinucleated myotube-like cells (strap cells). Electron microscopy demonstrated characteristic cytoplasmic bundles of myofilaments and Z-stripes within the strap cells. Immunoreactivity for vimentin was observed in the small spindle-shaped cells and for desmin in the strap cells. The results are consistent with the spectrum of findings characteristic for a bovine congenital embryonal rhabdomyosarcoma.
在伴侣动物中，具有骨骼肌分化的肿瘤很罕见。它们可分为良性横纹肌瘤和恶性横纹肌肉瘤。一头雌性德国荷斯坦小牛在头部侧面有一个先天性球形皮下肿块。组织学检查显示，这是一个有包膜、可膨胀、细胞高度丰富的肿块，由中等多形性的小梭形至圆形细胞组成的网状结构构成，位于纤维血管性至黏液样基质中，还有多灶性、大的、钝圆的、多核的肌管样细胞（带状细胞）。电子显微镜显示带状细胞内有特征性的肌丝胞质束和Z线。小梭形细胞中观察到波形蛋白免疫反应性，带状细胞中观察到结蛋白免疫反应性。这些结果与牛先天性胚胎性横纹肌肉瘤的特征性发现谱一致。
