Tanizaki Y, Sudo M, Kitani H, Araki H, Oki K, Soda R, Tada S, Takahashi K, Kimura I
Arerugi. 1989 Feb;38(2):68-73.
The various components making for severe intractable asthma were clinically and allergo-immunologically studied in 90 patients with bronchial asthma, by comparison between early onset and late onset groups. 1. In the early onset asthma group, cases with low serum IgE levels showed a stronger tendency toward severe intractable asthma. 2. Late onset asthma cases with negative skin tests and negative specific IgE antibodies to house dust tended more often to be severe intractable cases. 3. There was no correlation between sensitization by specific antigens (house dust and Candida), especially Candida, and a tendency toward severe intractable asthma. 4. Severe intractable asthma might be caused by bronchospasm in cases under 30 years of age, by bronchospasm plus hypersecretion in cases between 31 and 40 years of age, and by bronchospasm plus bronchiolar obstruction in cases over 40 years of age.
通过对90例支气管哮喘患者进行早发型和晚发型分组比较，从临床和变应性免疫角度对导致严重难治性哮喘的各种因素进行了研究。1. 早发型哮喘组中，血清IgE水平低的病例更易出现严重难治性哮喘倾向。2. 皮肤试验阴性且对屋尘特异性IgE抗体阴性的晚发型哮喘病例更常为严重难治性病例。3. 特定抗原（屋尘和念珠菌，尤其是念珠菌）致敏与严重难治性哮喘倾向之间无相关性。4. 严重难治性哮喘在30岁以下患者中可能由支气管痉挛引起，在31至40岁患者中由支气管痉挛加分泌亢进引起，在40岁以上患者中由支气管痉挛加细支气管阻塞引起。
