Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
Adv Mater. 2014 Jul 9;26(26):4497-503. doi: 10.1002/adma.201400953. Epub 2014 Apr 16.
A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties.
采用微流控技术，将多孔硅纳米粒子与粘膜黏附聚合物偶联，并随后封装到 pH 响应性聚合物中，构建了一种多功能的纳米级-微级药物传递平台。该多级平台显示出单分散的粒径分布和 pH 响应性的载药释放，并且释放的纳米粒子具有粘膜黏附性。此外，该平台还能够同时装载和释放具有不同性质的多种药物。
