参附注射液对大鼠实验性急性胰腺炎的保护作用
The protective effects of Shen-Fu injection on experimental acute pancreatitis in a rat model.
作者信息
Huang Lei, Cao Jun
机构信息
Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China.
Department of General Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China.
出版信息
Oxid Med Cell Longev. 2014;2014:248786. doi: 10.1155/2014/248786. Epub 2014 Mar 5.
OBJECTIVES
In the present study, we investigated the protective effects of Shen-Fu injection (SFI) on a caerulein-induced rat pancreatitis (AP) model.
METHODS
SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies.
RESULTS
Our results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein.
CONCLUSION
Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB) activity.
目的
在本研究中，我们研究了参附注射液（SFI）对雨蛙肽诱导的大鼠胰腺炎（AP）模型的保护作用。
方法
通过腹腔注射将SFI给予SFI治疗组的大鼠。采集血液和胰腺样本用于血清学和组织病理学研究。
结果
我们的结果表明，AP导致组织谷胱甘肽（GSH）、血清IL-4和IL-10显著降低，而胰腺丙二醛（MDA）和髓过氧化物酶（MPO）增加。此外，TNF-α、IL-1β、淀粉酶和脂肪酶水平也显著升高。另一方面，SFI治疗保留了所有这些生化指标以及由雨蛙肽诱导的组织病理学改变。
结论
我们的研究结果表明，SFI通过调节细胞因子、氧化应激和核因子-κB（NF-κB）活性来保护大鼠免受雨蛙肽诱导的AP。
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