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[环孢素治疗急慢性丙型病毒性肝炎]

[Cycloferon therapy of acute and chronic virus hepatitis C].

作者信息

Malyĭ V P, Pen'kov D V, Chiriukina O I

出版信息

Antibiot Khimioter. 2013;58(9-10):34-40.

Abstract

Complex clinical and laboratory examination of patients with HCV infection revealed that the use of cycloferon provided earlier normalization of the clinical and biochemical parameters and lower immunological imbalance vs. the basic therapy alone. High antiviral effect of the drug was shown. There was observed a positive impact of the cycloferon therapy on the late aftereffects hepatitis C, evidemt from higher frequency of the remissions in the patients with chronic hepatitis B and less frequent transformation of the acute form to the chronic one. Higher interferon-inducing and antiviral activities of cycloferon in the patients with acute hepatitis C and possible less frequent unfavourable aftereffects in the therapy with cycloferon in a dose of 500 mg were demonstrated.

摘要

对丙型肝炎病毒(HCV)感染患者进行的复杂临床和实验室检查显示,与单纯基础治疗相比,使用环孢素能使临床和生化参数更早恢复正常,且免疫失衡程度更低。该药物显示出较高的抗病毒效果。观察到环孢素治疗对丙型肝炎晚期后遗症有积极影响,这体现在慢性乙型肝炎患者缓解频率更高,以及急性形式向慢性形式转化频率更低。在急性丙型肝炎患者中,环孢素具有更高的干扰素诱导和抗病毒活性,并且在500毫克剂量的环孢素治疗中,可能出现不良后遗症的频率更低。

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