Romantsov M G, Sologub T V, Shul'diakov A A, Goriacheva L G, Lin'kova Iu N, Kovalenko A L
Eksp Klin Farmakol. 2010 Nov;73(11):30-3.
During treatment of patients with chronic hepatitis B the best therapeutic effect was obtained with the inclusion in the scheme of antiviral therapy cycloferon. Complete stable remission was achieved in 54.1% of patients in combination cycloferon with lamivudin, but the appointment of alpha-interferon with cycloferon provided remission 44.1% of patients resistant to treatment with lamivudin. Therapy of chronic hepatitis B with cycloferon can reduce the frequency and severity of side effects, prevents the development of resistance to lamivudin and the emergence of mutant viruses.
在慢性乙型肝炎患者的治疗过程中，抗病毒治疗方案中加入环孢素可获得最佳治疗效果。54.1%接受环孢素与拉米夫定联合治疗的患者实现了完全稳定缓解，但使用α干扰素与环孢素联合治疗使44.1%对拉米夫定治疗耐药的患者病情得到缓解。用环孢素治疗慢性乙型肝炎可降低副作用的发生频率和严重程度，防止对拉米夫定产生耐药性以及出现突变病毒。
