Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of Bordeaux, F-33000, Bordeaux, France.
Eur J Neurosci. 2014 Jun;39(11):1835-44. doi: 10.1111/ejn.12590. Epub 2014 Apr 17.
Kainate receptors (KARs) consist of a family of ionotropic glutamate receptors composed of the combinations of five subunits, GluK1-GluK5. Although KARs display close structural homology with AMPA receptors, they serve quite distinct functions. A great deal of our knowledge of the molecular and functional properties of KARs comes from their study in the hippocampus. This review aims at summarising the functions of KARs in the regulation of the activity of hippocampal synaptic circuits at the adult stage and throughout development. We focus on the variety of roles played by KARs in physiological conditions of activation, at pre- and postsynaptic sites, in different cell types and through either metabotropic or ionotropic actions. Finally, we present some of the few attempts to link the role of KARs in the regulation of local hippocampal circuits to the behavioural functions of the hippocampus in health and diseases.
kainate 受体 (KARs) 由一组离子型谷氨酸受体组成，由 GluK1-GluK5 这 5 个亚基的组合构成。虽然 KARs 与 AMPA 受体具有密切的结构同源性，但它们具有截然不同的功能。我们对 KAR 分子和功能特性的大量了解来自于它们在海马体中的研究。本综述旨在总结 KAR 在成年期和整个发育过程中调节海马突触回路活性的功能。我们专注于 KAR 在各种激活条件下、在突触前和突触后部位、在不同细胞类型中以及通过代谢型或离子型作用发挥的多种作用。最后，我们介绍了一些将 KAR 在局部海马回路调节中的作用与海马在健康和疾病中的行为功能联系起来的尝试。
