在大鼠脑突触体中，刺尾鱼毒素可阻断钙激活钾通道和非钙依赖性电压门控钾通道。
Charybdotoxin blocks both Ca-activated K channels and Ca-independent voltage-gated K channels in rat brain synaptosomes.
作者信息
Schneider M J, Rogowski R S, Krueger B K, Blaustein M P
机构信息
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.
出版信息
FEBS Lett. 1989 Jul 3;250(2):433-6. doi: 10.1016/0014-5793(89)80771-9.
Charybdotoxin (ChTX), a 4.3 kDa polypeptide toxin from the venom of the scorpion Leiurus quinquestriatus, blocks both a Ca-activated K channel (IC50 approximately 15 nM) and a Ca-independent voltage-gated K channel (IC50 approximately 40 nM) in rat brain synaptosomes. These results indicate that in this preparation ChTX is not specific for the Ca-activated K channel and suggest that there may be structural homology among the toxin-binding sites on various types of K channels.
卡律蝎毒素（ChTX）是一种来自金蝎毒液的4.3千道尔顿多肽毒素，它可阻断大鼠脑突触体中的一种钙激活钾通道（半数抑制浓度约为15纳摩尔）和一种非钙依赖性电压门控钾通道（半数抑制浓度约为40纳摩尔）。这些结果表明，在此制剂中，ChTX对钙激活钾通道不具有特异性，并提示不同类型钾通道上的毒素结合位点之间可能存在结构同源性。
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