Al-Amin Md Mamun, Reza Hasan M
Department of Pharmaceutical Sciences, North South University, SAC#950, Plot 15, Block B, Bashundhara, Dhaka 1229, Bangladesh. Tel. +88 01927077102. Fax. +88 (2) 8852016. E-mail:
Neurosciences (Riyadh). 2014 Apr;19(2):87-92.
We investigated the idea of possible anti-inflammatory treatment approaches for inflammatory disorders in the CNS. The articles used for this review were searched through PubMed, PsycINFO, and Google scholar and published between January 2000 and July 2013. The CNS has its own type of defensive mechanism. The crosstalk between neurons and the immune system take place via small molecules called cytokines that are secreted from glial cells. Previous study suggested that the imbalance of cytokines facilitates the development of CNS disorders. For instance, the interleukin-6 level is raised in the astrocyte cell during depressive episodes, while axons are damaged by the activated lymphocytes and microglia in multiple sclerosis. Several studies demonstrated that cytokines and inflammatory compounds are closely linked to neuropsychiatric and neurodegenerative disorders. Here, we have accumulated and summarized evidence from those papers that support the anti-inflammatory treatment options for inflammatory CNS disorders.
我们研究了针对中枢神经系统炎症性疾病的可能抗炎治疗方法的想法。本综述所用文章通过PubMed、PsycINFO和谷歌学术进行检索，发表时间为2000年1月至2013年7月。中枢神经系统有其自身的防御机制类型。神经元和免疫系统之间的相互作用是通过神经胶质细胞分泌的称为细胞因子的小分子进行的。先前的研究表明，细胞因子失衡会促进中枢神经系统疾病的发展。例如，在抑郁发作期间，星形胶质细胞中的白细胞介素-6水平会升高，而在多发性硬化症中，轴突会被活化的淋巴细胞和小胶质细胞损伤。多项研究表明，细胞因子和炎症化合物与神经精神疾病和神经退行性疾病密切相关。在此，我们积累并总结了那些支持针对炎症性中枢神经系统疾病进行抗炎治疗选择的论文中的证据。
