Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143;
J Immunol. 2014 May 15;192(10):4492-6. doi: 10.4049/jimmunol.1303211. Epub 2014 Apr 16.
CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activating CD94-NKG2C receptor that persist after control of the infection. We investigated whether this subset is CMV specific or is also responsive to acute infection with EBV. We describe a longitudinal study of CMV(-) and CMV(+) students who were acutely infected with EBV. The NKG2C(hi) NK subset was not expanded by EBV infection. However, EBV infection caused a decrease in the absolute number of immature CD56(bright)CD16(-) NK cells in the blood and, in CMV(+) individuals, induced an increased frequency of mature CD56(dim)NKG2A(+)CD57(+) NK cells in the blood that persisted into latency. These results provide further evidence that NKG2C(+) NK cells are CMV specific and suggest that EBV infection alters the repertoire of NK cells in the blood.
巨细胞病毒（CMV）诱导表达高水平激活型 CD94-NKG2C 受体的独特人类 NK 细胞亚群扩增，这种扩增在感染得到控制后仍然存在。我们研究了这个亚群是否是 CMV 特异性的，还是也对 EBV 的急性感染有反应。我们描述了一项对 CMV（-）和 CMV（+）学生的纵向研究，他们急性感染 EBV。EBV 感染并没有使 NKG2C（hi）NK 亚群扩增。然而，EBV 感染导致血液中不成熟 CD56（bright）CD16（-）NK 细胞的绝对数量减少，并且在 CMV（+）个体中，诱导血液中成熟 CD56（dim）NKG2A（+）CD57（+）NK 细胞的频率增加，这种增加持续到潜伏阶段。这些结果进一步证明了 NKG2C（+）NK 细胞是 CMV 特异性的，并表明 EBV 感染改变了血液中 NK 细胞的 repertoire。
