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癌胚抗原和角蛋白在表皮源性肿瘤中分布的免疫组织化学研究。I:鳞状上皮瘤和基底细胞上皮瘤

[Immunohistochemical study of the distribution of carcinoembryonic antigen and keratin in tumors of epidermal origin. I: Squamous and basal cell epitheliomas].

作者信息

Betlloch Mas I, Castells Rodellas A

机构信息

Cátedra de Dermatología, Hospital Clínico Universitario de Valencia.

出版信息

Med Cutan Ibero Lat Am. 1989;17(2):121-6.

PMID:2474116
Abstract

Carcinoembryonic antigen (CEA) has been studied extensively, in association with visceral tumors and normal tissues. Although CEA has been demonstrated in sweat gland cutaneous tumors, little is known about its presence in skin and epithelial related tumors. We studied the presence of CEA and keratin in squamous cell and basal cell carcinoma using immunohistochemical techniques. Its distribution related with differentiation, proliferation and malignant potential is observed. The expression of both antigens is correlated.

摘要

癌胚抗原(CEA)已被广泛研究,涉及内脏肿瘤和正常组织。尽管在汗腺皮肤肿瘤中已证实存在CEA,但对其在皮肤和上皮相关肿瘤中的存在情况知之甚少。我们使用免疫组织化学技术研究了鳞状细胞癌和基底细胞癌中CEA和角蛋白的存在情况。观察了其与分化、增殖和恶性潜能相关的分布。两种抗原的表达具有相关性。

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