Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA; Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, USA.
Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA; Department of Neurology, University of California at San Francisco, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA; Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
Psychiatry Res. 2014 Jun 30;222(3):119-23. doi: 10.1016/j.pscychresns.2014.03.005. Epub 2014 Mar 19.
Numerous imaging studies have reported smaller hippocampal volumes in patients with PTSD. To investigate whether decreased hippocampal volume is associated with PTSD chronicity, independent of age, we used hierarchical linear regression to examine the relationship between PTSD duration (estimated from the amount of time that had elapsed since the traumatic event; mean=17 years; range=6-36 years) and hippocampal volume, adjusting for age and other factors. Freesurfer version 4.5 was used to quantify the volumes of the hippocampus and the caudate nucleus, which served as a "control" region, from the 1.5T Magnetic Resonance Images (MRI) of 55 combat veterans (mean age 45±9 years) with chronic and current PTSD. PTSD duration was significantly associated with right hippocampal volume (β=-0.34, t=-2.40, P=0.02) after accounting for intracranial volume, age, gender (entered in the first step) and comorbidities (e.g., early life trauma, current major depression, history of substance abuse/dependence, psychotropic medication use, entered in the second step). This finding provides support for the potential neurotoxic effects of PTSD on hippocampal volume.
大量影像学研究报告称，创伤后应激障碍（PTSD）患者的海马体体积较小。为了研究海马体体积的减小是否与 PTSD 的慢性病程有关，而与年龄无关，我们使用分层线性回归来检验 PTSD 持续时间（根据创伤事件发生后的时间长短来估计；平均值为 17 年；范围为 6-36 年）与海马体体积之间的关系，同时调整了年龄和其他因素。使用 Freesurfer 版本 4.5 从 55 名患有慢性和当前 PTSD 的参战老兵（平均年龄 45±9 岁）的 1.5T 磁共振成像（MRI）中定量计算了海马体和尾状核的体积，尾状核作为“对照”区域。在考虑了脑容量、年龄、性别（在第一步中输入）和合并症（例如，早年创伤、当前重度抑郁症、物质滥用/依赖史、精神药物使用）后，PTSD 持续时间与右侧海马体体积呈显著负相关（β=-0.34，t=-2.40，P=0.02）。这一发现为 PTSD 对海马体体积的潜在神经毒性影响提供了支持。
