INSERM U791, Université de Nantes, Faculté de Chirurgie Dentaire, 44042 Nantes, France.
Univ Nice Sophia Antipolis, CNRS, iBV, UMR7277, UFR Médecine, 06107 Nice Cedex 2, France.
Drug Discov Today. 2014 Sep;19(9):1419-26. doi: 10.1016/j.drudis.2014.04.004. Epub 2014 Apr 14.
The recent progress in oncologic management of patients with localized cancer or metastatic disease has permitted a significant improvement in life expectancy. Nevertheless, bone metastases and their consequent skeletal-related events (SREs) are still associated with unfavorable prognosis and greatly affect quality of life. Global management of these bone metastases includes traditional local approaches (surgery, radiotherapy, etc.) and systemic administration of chemotherapeutic agents. This review focuses on treatments specific for bone metastases and, in particular, on inhibitors of bone resorption that are effective for preventing and delaying the development of SREs.
近年来，局部癌症或转移性疾病患者的肿瘤治疗取得了显著进展，使得患者的预期寿命显著延长。然而，骨转移及其导致的骨骼相关事件（SREs）仍然与不良预后相关，并严重影响生活质量。这些骨转移的全球管理包括传统的局部方法（手术、放疗等）和全身化疗药物的应用。本文重点介绍了针对骨转移的特定治疗方法，特别是骨吸收抑制剂，它们可有效预防和延缓 SREs 的发生。
