Galietta L J, Mastrocola T, Nobile M
Laboratorio di Genetica Molecolare, Istituto G. Gaslini, Genova, Italy.
FEBS Lett. 1989 Aug 14;253(1-2):43-6. doi: 10.1016/0014-5793(89)80925-1.
Non-selective cation channels were detected in membrane patches of cultured human fibroblasts. The channels had a unitary conductance which ranged from 14 to 25 pS in symmetrical 130 mM NaCl and were permeable to both sodium and potassium ions. Open channel probability was dependent either on the membrane potential and the Ca2+ concentration on the intracellular side of the membrane. High Ca2+ concentrations in the millimolar range were needed to keep the channel active.
在培养的人成纤维细胞膜片上检测到了非选择性阳离子通道。这些通道的单位电导在对称的130 mM NaCl中为14至25 pS，对钠离子和钾离子都具有通透性。通道开放概率取决于膜电位以及膜内侧的Ca2+浓度。需要毫摩尔范围内的高Ca2+浓度来保持通道活性。
