一名B细胞前体急性淋巴细胞白血病患儿的JAK2基因中发现一种新型纯合核苷酸缺失 - Suppr

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A Novel Homozygous Nucleotide Deletion in the JAK2 Gene in a Pediatric Patient with B-cell Precursor Acute Lymphoblastic Leukemia.

作者信息

Akın Dilara Fatma, Akkaya Emel, Kürekçi A Emin, Arslan Ciğdem, Ezer Ustün, Akar Nejat

机构信息

LOSEV Foundation for Children with Leukemia, Ankara, Turkey.

Ankara University, Department of Pediatric Genetics, Ankara, Turkey.

出版信息

Turk J Haematol. 2012 Jun;29(2):185-7. doi: 10.5505/tjh.2012.44712. Epub 2012 Jun 15.

DOI:10.5505/tjh.2012.44712

PMID:24744653

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3986960/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d1/3986960/750aa131d5d4/TJH-29-185-g1.jpg

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Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.CRLF2 重排与 JAK 激酶突变、IKZF1 改变、西班牙裔/拉丁裔种族和儿童 B 祖细胞急性淋巴细胞白血病不良预后相关。

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