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Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2).

作者信息

Jones Brandon M, Bhattacharjee Surjyadipta, Dua Prerna, Hill James M, Zhao Yuhai, Lukiw Walter J

机构信息

LSU Neuroscience Center, Louisiana State University Health Sciences Center (LSUHSC) New Orleans, LA, USA.

Department of Health Information Management, Louisiana State University Ruston, LA, USA.

出版信息

Front Cell Neurosci. 2014 Mar 31;8:94. doi: 10.3389/fncel.2014.00094. eCollection 2014.

DOI:10.3389/fncel.2014.00094
PMID:24744699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3978349/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/3978349/ee87811ad588/fncel-08-00094-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/3978349/ee87811ad588/fncel-08-00094-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/3978349/ee87811ad588/fncel-08-00094-g0001.jpg

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本文引用的文献

1
TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis.TREM2 变体 p.R47H 是散发性肌萎缩侧索硬化症的风险因素。
JAMA Neurol. 2014 Apr;71(4):449-53. doi: 10.1001/jamaneurol.2013.6237.
2
Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice.髓样细胞表达的触发受体2基因敲低会加剧衰老加速小鼠易感8型小鼠与衰老相关的神经炎症和认知缺陷。
Neurobiol Aging. 2014 Jun;35(6):1243-51. doi: 10.1016/j.neurobiolaging.2013.11.026. Epub 2013 Dec 2.
3
TREM2 and the neuroimmunology of Alzheimer's disease.
脂多糖处理的 APP/PS1 转基因小鼠小胶质细胞 TLR4/TREM2 失衡：阿尔茨海默病与全身炎症之间的潜在联系。
Neurochem Res. 2019 May;44(5):1138-1151. doi: 10.1007/s11064-019-02748-x. Epub 2019 Feb 12.
4
Elucidating the Interactive Roles of Glia in Alzheimer's Disease Using Established and Newly Developed Experimental Models.利用已建立的和新开发的实验模型阐明神经胶质细胞在阿尔茨海默病中的相互作用作用。
Front Neurol. 2018 Sep 26;9:797. doi: 10.3389/fneur.2018.00797. eCollection 2018.
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Metab Brain Dis. 2017 Oct;32(5):1335-1355. doi: 10.1007/s11011-017-0077-2. Epub 2017 Jul 27.
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Acta Neuropathol Commun. 2016 Mar 16;4:25. doi: 10.1186/s40478-016-0293-8.
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Int J Mol Sci. 2015 Dec 17;16(12):30105-16. doi: 10.3390/ijms161226223.
10
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J Nat Sci. 2015 Jul;1(7).
TREM2 与阿尔茨海默病的神经免疫。
Biochem Pharmacol. 2014 Apr 15;88(4):495-8. doi: 10.1016/j.bcp.2013.11.021. Epub 2013 Dec 16.
4
The innate immune system in Alzheimer's disease.阿尔茨海默病中的固有免疫系统。
Int J Cell Biol. 2013;2013:576383. doi: 10.1155/2013/576383. Epub 2013 Oct 2.
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TREM2 and neurodegenerative disease.触发受体表达于髓细胞2（TREM2）与神经退行性疾病
N Engl J Med. 2013 Oct 17;369(16):1569-70. doi: 10.1056/NEJMc1306509.
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J Inorg Biochem. 2013 Nov;128:267-9. doi: 10.1016/j.jinorgbio.2013.05.010. Epub 2013 May 29.
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Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer's disease (AD)-anti-NF-κB vs. anti-miRNA strategies.散发性阿尔茨海默病（AD）中NF-κB上调的微小RNA（miRNA）的拮抗作用——抗NF-κB与抗miRNA策略对比
Front Genet. 2013 May 1;4:77. doi: 10.3389/fgene.2013.00077. eCollection 2013.
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Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a.由NF-кB敏感的miRNA-34a对触发受体表达分子2（TREM2）表达的调控
Neuroreport. 2013 Apr 17;24(6):318-23. doi: 10.1097/WNR.0b013e32835fb6b0.
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microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF).阿尔茨海默病（AD）脑脊液（CSF）和细胞外液（ECF）中的微小RNA（miRNA）物种形成。
Int J Biochem Mol Biol. 2012;3(4):365-73. Epub 2012 Dec 24.