Rosales-Velderrain Armando, Padilla Michael, Choe Charles H, Hargens Alan R
Department of Orthopaedic Surgery, University of California San Diego, San Diego, California.
Physiol Rep. 2013 Dec 19;1(7):e00157. doi: 10.1002/phy2.157. eCollection 2013 Dec 1.
Intermittent pneumatic compression of the calf and foot increases inflow to the popliteal artery and skin. We hypothesize that mild, continuous pneumatic compression of the lower extremities of type 2 diabetic patients increases microvascular blood flow to skin (SBF) and muscle (MBF) and improves sensation in feet. Data were collected on 19 healthy volunteers and 16 type 2 diabetic patients. Baseline values of SBF, MBF, and foot sensation were recorded in one leg. The lower extremity was then subjected to 30 mmHg of continuous external air pressure for 30 min, whereas SBF and MBF were continuously monitored. Sensation was reassessed after pressure was released. During 30 mmHg continuous external compression, the healthy control group significantly increased MBF by 39.8% (P < 0.01). Sensation of the foot in this group improved significantly by 49.8% (P < 0.01). In the diabetic group, there was a significant increase in MBF of 17.7% (P = 0.03). Also sensation improved statistically by 40.2% (P = 0.03). Importantly and counterintuitively, MBF and foot sensation both increase after 30 min of leg compression at 30 mmHg. Therefore, mild, continuous pneumatic compression may be a new approach for treating diabetic patients with compromised leg perfusion and sensation.
对小腿和足部进行间歇性气动压迫可增加腘动脉和皮肤的血流量。我们推测，对2型糖尿病患者的下肢进行轻度、持续的气动压迫可增加皮肤（SBF）和肌肉（MBF）的微血管血流量，并改善足部感觉。收集了19名健康志愿者和16名2型糖尿病患者的数据。记录一条腿的SBF、MBF和足部感觉的基线值。然后对下肢施加30 mmHg的持续外部气压30分钟，同时持续监测SBF和MBF。压力释放后重新评估感觉。在30 mmHg持续外部压迫期间，健康对照组的MBF显著增加39.8%（P < 0.01）。该组足部感觉显著改善49.8%（P < 0.01）。在糖尿病组中，MBF显著增加17.7%（P = 0.03）。感觉在统计学上也改善了40.2%（P = 0.03）。重要且与直觉相反的是，在30 mmHg对腿部进行30分钟压迫后，MBF和足部感觉均增加。因此，轻度、持续的气动压迫可能是治疗腿部灌注和感觉受损的糖尿病患者的一种新方法。
