Sroczyńska Patrycja
Postepy Biochem. 2013;59(4):365-71.
Endothelial and hematopoietic lineages have long been thought to develop from a common ancestor, the hemangioblast. Alternatively, clusters of hematopoietic cells in the dorsal aorta were observed to form in a close association with endothelial wall of the aorta, leading to the hypothesis that a special subset of endothelial cells, called the hemogenic endothelium, generates hematopoietic cells. Recent advances in time-lapse imaging, conditional labeling of cells in vivo and embryonic stem cell differentiation provided new evidence for the existence of both, the hemangioblast and hemogenic endothelium. Importantly, these seemingly contradictory theories can be merged into one model of hematopoietic differentiation from mesoderm.
长期以来，内皮细胞系和造血细胞系一直被认为起源于一个共同的祖先——成血管细胞。另外，有人观察到背主动脉中的造血细胞簇与主动脉的内皮壁紧密相连，这导致了一种假说，即一种特殊的内皮细胞亚群，称为造血内皮，可产生造血细胞。延时成像、体内细胞的条件标记和胚胎干细胞分化方面的最新进展为成血管细胞和造血内皮的存在提供了新证据。重要的是，这些看似相互矛盾的理论可以融合成一个从中胚层进行造血分化的模型。
