Allergy Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Aristide Stefani 1, Verona 37126, Italy.
Allergy Unit, Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Aristide Stefani 1, Verona 37126, Italy.
Immunol Allergy Clin North Am. 2014 May;34(2):397-405. doi: 10.1016/j.iac.2014.01.014. Epub 2014 Mar 13.
Drugs are known triggers of anaphylaxis in patients with mastocytosis even to the association between drug anaphylaxis and mastocytosis does not appear frequently appear. Nevertheless, mast cell disorders might be ruled out in cases of severe systemic reactions. Careful examination of the skin should accompany measurement of basal serum tryptase levels. The data published about drug anaphylaxis in patients with mast cell disorders are scarce, and it is not currently possible to provide clear recommendations. Most papers report cases of anaphylaxis during surgical procedures or radiocontrast media exposure. There are no specific recommendations to prevent severe reactions during such procedures, although some specialists suggest performing premedication with antihistamines and corticosteroids before anesthesia or radiocontrast media administration.
药物已知是肥大细胞增多症患者发生过敏反应的触发因素，即使药物过敏反应和肥大细胞增多症之间的关联并不常见。然而，在严重的全身反应情况下，可能需要排除肥大细胞疾病。在测量基础血清类胰蛋白酶水平的同时，应仔细检查皮肤。关于肥大细胞疾病患者药物过敏反应的已发表数据很少，目前无法提供明确的建议。大多数论文报告了手术过程中或放射造影剂暴露期间发生过敏反应的病例。目前没有预防此类手术中严重反应的具体建议，尽管一些专家建议在麻醉或放射造影剂给药前进行抗组胺药和皮质类固醇的预处理。
