INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France.
INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France; Service de médecine Interne, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, 4 rue de la chine, Paris 75020, France.
Immunol Allergy Clin North Am. 2014 May;34(2):407-22. doi: 10.1016/j.iac.2014.02.001.
In approximately one-third of cases, patients with mastocytosis can display various disabling general and neuropsychological symptoms. General signs may have a major impact on quality of life. Neurologic symptoms are less frequent. In a majority of cases, the pathophysiology of these symptoms is not known but could be linked to tissular mast cell infiltration, mast cell mediator release, or both. Treatments aiming at reducing mast cell number and/or stabilizating mast cells may be useful. Preliminary results suggest that treatment with kinase inhibitors may improve symptoms of depression and cognitive impairment.
大约三分之一的肥大细胞增多症患者会表现出各种使人丧失能力的全身和神经心理症状。全身症状可能会对生活质量产生重大影响。神经症状则较为少见。这些症状的病理生理学大多尚不清楚，但可能与组织肥大细胞浸润、肥大细胞介质释放或两者兼有有关。旨在减少肥大细胞数量和/或稳定肥大细胞的治疗方法可能会有用。初步结果表明，使用激酶抑制剂治疗可能会改善抑郁和认知障碍的症状。
