Department of Haematology, Children's Hospital, Liebigstrasse 20a, 04103 Leipzig, Germany.
Thromb Res. 2014 Nov;134 Suppl 1:S57-60. doi: 10.1016/j.thromres.2013.10.018. Epub 2014 Apr 16.
The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this centre, early prophylaxis was offered to all patients with severe haemophilia A or B. For over 20 years, the treatments of choice in the German Democratic Republic were cryoprecipitate for haemophilia A and prothrombin complex concentrate for haemophilia B. Cryoprecipitate was relatively effective during minor surgery, in cases of mild to moderate bleeding, and for prophylaxis; however, unpleasant, relevant side-effects and hepatitis virus transmission were frequently encountered in clinical practice. Reunification coincided with the availability of virus-safe, high-purity plasma-derived factor VIII concentrates (e.g. Beriate(®) P), which changed the outlook for patients in terms of convenience, tolerability, and virus safety; and these new products quickly became the treatments of choice for haemophilia A patients at the Leipzig Children's Hospital. Today, 20 years later, nearly all of the patients initiated on Beriate(®) P at the time of reunification continue with that treatment, and are still benefitting from its excellent efficacy, tolerability, and virus-safety profile.
1990 年德国统一给血友病患者的护理带来了重大挑战。当时，大多数治疗中心都属于最大的区域医院。莱比锡儿科血友病治疗中心位于大学医院。在该中心，所有严重甲型或乙型血友病患者都采用早期预防治疗。在德意志民主共和国，20 多年来，甲型血友病的首选治疗方法是冷沉淀，乙型血友病的首选治疗方法是凝血酶原复合物浓缩物。冷沉淀在小手术、轻度至中度出血以及预防治疗时相对有效，但在临床实践中经常会遇到令人不快的相关副作用和肝炎病毒传播。统一恰逢病毒安全、高纯度血浆衍生的因子 VIII 浓缩物（例如 Beriate®P）的供应，这改变了患者在便利性、耐受性和病毒安全性方面的前景；这些新产品很快成为莱比锡儿童医院甲型血友病患者的首选治疗方法。20 年后的今天，几乎所有在统一时开始使用 Beriate®P 的患者仍继续接受该治疗，并且仍受益于其出色的疗效、耐受性和病毒安全性。
