Segami N, Fukuda M, Manabe T
Department of Oral and Maxillofacial Surgery, Kawasaki Medical School, Japan.
Int J Oral Maxillofac Surg. 1989 Jun;18(3):133-7. doi: 10.1016/s0901-5027(89)80108-0.
In order to gain insight into the origin of Warthin's tumor, 10 cases of Warthin's tumor were compared immunohistologically with macroscopically and microscopically normal areas of the same glands, using 6 types of functional markers; carcinoembryonic antigen, secretory component, lactoferrin, keratin, S-100 protein and glial fibrillary acidic protein. It was shown that in normal parotid glands, the cells of acini, the intercalated ducts, the striated ducts, and the excretory ducts, as well as myoepithelial cells differed from each other in intensity and distribution of reaction products with antisera against those markers. Although the differences were rather subtle, the results suggested that those markers could differentiate the cell types of the salivary glands. In Warthin's tumors with double-layered tumor epithelia, the staining characteristics of the luminal and basal epithelia differed from each other. Epithelial cells on the luminal side showed immunological characteristics similar to striated duct cells of the parotid gland, while those of the basal side had characteristics similar to those of basal cells of the excretory duct. It is therefore suggested that the epithelia of Warthin's tumor may show differentiation into 2 different cell types.
为深入了解沃辛瘤的起源，采用癌胚抗原、分泌成分、乳铁蛋白、角蛋白、S - 100蛋白和胶质纤维酸性蛋白6种功能标记物，对10例沃辛瘤与同一腺体的宏观及微观正常区域进行免疫组织学比较。结果显示，在正常腮腺中，腺泡细胞、闰管、纹状管、排泄管的细胞以及肌上皮细胞，在针对这些标记物的抗血清反应产物的强度和分布上彼此不同。尽管差异较为细微，但结果表明这些标记物可区分唾液腺的细胞类型。在具有双层肿瘤上皮的沃辛瘤中，腔面和基底上皮的染色特征彼此不同。腔面的上皮细胞显示出与腮腺纹状管细胞相似的免疫特征，而基底侧的上皮细胞具有与排泄管基底细胞相似的特征。因此提示沃辛瘤的上皮可能分化为2种不同的细胞类型。
