Department of Pathology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China.
Department of Pathology, Henry Ford Health System, Detroit, MI 48202, USA.
Hum Pathol. 2014 May;45(5):1115-21. doi: 10.1016/j.humpath.2013.12.017. Epub 2014 Jan 21.
Myopericytoma is a benign mesenchymal neoplasm thought to comprise part of a spectrum of perivascular myoid cell neoplasms with myofibroma, angioleiomyoma, and glomus tumor. We describe 2 such neoplasms involving the urinary tract: 1 incidentally identified in the kidney of a 59-year-old woman and 1 in the urinary bladder of a 52-year-old woman who presented with urinary frequency and dysuria. Histologically, the bladder tumor was composed of numerous blood vessels surrounded by plump perivascular myoid cells, as in subcutaneous myopericytoma. The renal tumor showed similar morphology centrally and a symplastic glomus tumor-like growth pattern at the periphery. Immunohistochemically, both tumors were reactive for markers of smooth muscle differentiation, such as smooth muscle actin and caldesmon/calponin but negative for CD34, cathepsin K, and S100 protein. Both patients are free of disease 14 and 39 months after resection, respectively. Our findings broaden the morphologic spectrum of myopericytoma.
肌周细胞瘤是一种良性间叶性肿瘤，被认为是血管周肌样细胞肿瘤谱的一部分，包括肌纤维瘤、血管平滑肌瘤和血管球瘤。我们描述了 2 例发生在泌尿道的此类肿瘤：1 例发生在 59 岁女性的肾脏中，另 1 例发生在 52 岁女性的膀胱中，她们均表现为尿频和尿痛。组织学上，膀胱肿瘤由许多血管周围的丰满的血管周肌样细胞组成，类似于皮下肌周细胞瘤。肾脏肿瘤在中央表现出相似的形态，在边缘表现出类似交感神经球瘤样的生长模式。免疫组化染色，这两种肿瘤均对平滑肌分化标志物如平滑肌肌动蛋白和钙调蛋白/钙调蛋白阳性，但对 CD34、组织蛋白酶 K 和 S100 蛋白阴性。两名患者分别在切除后 14 个月和 39 个月时无疾病复发。我们的研究结果拓宽了肌周细胞瘤的形态学谱。
