Goudsmit J, Bakker M, Smit L, Meloen R H
Human Retrovirus Laboratory, Academic Medical Center, Amsterdam, The Netherlands.
J Med Primatol. 1989;18(3-4):357-62.
Sera from three chimpanzees infected with a primary lymphadenopathy-associated virus (LAV-1) or human T-lymphotropic virus type III (HTLV-IIIB) passage, from two chimpanzees infected with blood from the primary infected chimpanzees, and from one chimpanzee infected with blood from a secondary passage animal all bound the peptides 3B and 3B/RF, sharing the sequence IQRGPGR, with equally high titers. Pepscan analysis confirmed the amino acids Q, R, G, P, and G as irreplaceable in order to retain antigenicity.
来自三只感染原发性淋巴结病相关病毒（LAV-1）或III型人类嗜T淋巴细胞病毒（HTLV-IIIB）传代病毒的黑猩猩的血清，来自两只感染原发性感染黑猩猩血液的黑猩猩的血清，以及来自一只感染二代传代动物血液的黑猩猩的血清，均以同样高的滴度结合了具有IQRGPGR序列的肽3B和3B/RF。肽扫描分析证实，氨基酸Q、R、G、P和G对于保留抗原性而言不可替代。
