5-氮杂胞苷对骨髓基质细胞基因表达的影响。
Effect of 5-azacytidine on gene expression in marrow stromal cells.
作者信息
Andrews D F, Nemunaitis J, Tompkins C, Singer J W
机构信息
Medical Service, VA Medical Center, Seattle, Washington 98108.
出版信息
Mol Cell Biol. 1989 Jun;9(6):2748-51. doi: 10.1128/mcb.9.6.2748-2751.1989.
Abstract
When exposed to 5-azacytidine, marrow stromal cells from active long-term marrow cultures and cell lines derived from simian virus 40-transformed stromal cells rapidly upregulated c-abl and interleukin-6 transcripts while downregulating the expression of collagen I, a major matrix protein. Similar effects occurred with interleukin-1 alpha and tumor necrosis factor alpha, although the time course was considerably prolonged.
摘要
当暴露于5-氮杂胞苷时，来自长期活跃骨髓培养物的骨髓基质细胞以及源自猿猴病毒40转化的基质细胞的细胞系会迅速上调c-abl和白细胞介素-6转录本，同时下调主要基质蛋白I型胶原蛋白的表达。白细胞介素-1α和肿瘤坏死因子α也会产生类似的效果，尽管时间进程会显著延长。
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