Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis.
作者信息
Hutson P H, Sarna G S, O'Connell M T, Curzon G
机构信息
Department of Neurochemistry, Institute of Neurology, London, U.K.
出版信息
Neurosci Lett. 1989 May 22;100(1-3):276-80. doi: 10.1016/0304-3940(89)90698-8.
PMID:2474776
Abstract
Infusion of the serotonin-1A (5-HT1A) agonist, 8-hydroxy-2-di(n-propylamino)tetralin (8-OHDPAT) (0.5, 1.0 and 2.0 micrograms) into the dorsal raphe, decreased extracellular 5-HT as measured by dialysis in the ventral hippocampus and also decreased 5-HT synthesis in both the hippocampus and the rest of the brain as measured by 5-hydroxytryptophan (5-HTP) accumulation following decarboxylase inhibition by NSD 1015.
摘要
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