Baker G B, Reynolds G P
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Neurosci Lett. 1989 May 22;100(1-3):335-9. doi: 10.1016/0304-3940(89)90709-x.
The following monoamine transmitters and related neurochemicals were analyzed in hippocampus and substantia innominata from postmortem brain tissue of subjects with senile dementia of the Alzheimer's type (SDAT): tryptophan (TP), 5-hydroxytryptamine (5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA), noradrenaline (NA), dopamine (DA) and homovanillic acid (HVA). The results were compared to those obtained in postmortem brain samples obtained from normal subjects matched for age, sex and time between collection of tissue and freezing. There were no significant differences in concentrations of TP, DA or HVA between normals and SDAT subjects in either brain region. While hippocampal 5-HT, 5-HIAA and NA concentrations were markedly reduced in SDAT patients relative to normals, the substantia innominata concentrations of these three were not significantly different between controls and SDAT patients, emphasizing the importance of detailed regional analyses when conducting neurochemical studies in SDAT.
对阿尔茨海默型老年痴呆症（SDAT）患者死后脑组织的海马体和无名质中的以下单胺类递质及相关神经化学物质进行了分析：色氨酸（TP）、5-羟色胺（5-HT）、5-羟吲哚-3-乙酸（5-HIAA）、去甲肾上腺素（NA）、多巴胺（DA）和高香草酸（HVA）。将结果与从年龄、性别以及组织采集到冷冻的时间相匹配的正常受试者的死后脑样本中获得的结果进行比较。在两个脑区中，正常人和SDAT患者的TP、DA或HVA浓度均无显著差异。虽然与正常人相比，SDAT患者海马体中的5-HT、5-HIAA和NA浓度显著降低，但对照组和SDAT患者无名质中这三种物质的浓度并无显著差异，这强调了在SDAT中进行神经化学研究时详细区域分析的重要性。
