Dumic-Cule Ivo, Eljuga Domagoj, Izadpanah Ali, Erjavec Igor, Prgomet Stefan, Hladnik Ana, Bicanic Ivana, Rora Mia, Vinter Ivan, Grgurevic Lovorka
Department of Anatomy, School of Medicine, University of Zagreb, Salata 11, 10000, Zagreb, Croatia.
Surg Radiol Anat. 2014 Dec;36(10):989-92. doi: 10.1007/s00276-014-1296-4. Epub 2014 Apr 19.
Numerous studies have attempted to clarify the exact anatomy and variations of the optic canal with non-conclusive results due to its close proximity to many vulnerable structures. We sought to determine the dynamics of growth and development of these structures on fetal skulls, which will help us to better understand of gender and age-dependent variations, as well as fatal malformations.
Fifteen previously macerated fetal frontal and sphenoid bones were analyzed and the diameters of optic canal, and distance of orbit from frontomaxillary suture to frontozygomatic suture were measured using 3D reconstruction images obtained by micro-CT.
Average diameter of the optic canal in 300 mm fetus was measured to be 1,546 ± 36 µm, in 400 mm fetus 2,470 ± 123 µm and in 500 mm fetus 3,757 ± 203 µm. This trend indicates a linear enlargement of optic canal during the fetal period. During the same time period, diameter of the orbit enlarges from 12,319 ± 559 µm in 300 mm fetus to 19,788 ± 736 µm in 500 mm fetus. Growth curve is significantly lower in comparison with the same curve in optic canal data. We also calculated the ratio of orbit diameter and optic canal diameter between those groups which decreased from a value of 7.9 ± 0.4 for 300 mm fetus to 5.3 ± 0.2 for 500 mm fetus.
Dynamics of optic canal and orbital cavity development is different in early and late fetal period. Diameters of those structures are in better correlation with the fetal length.
由于视神经管紧邻许多脆弱结构，众多研究试图阐明其确切解剖结构及变异情况，但结果尚无定论。我们试图确定这些结构在胎儿颅骨上的生长发育动态，这将有助于我们更好地理解性别和年龄相关的变异以及致命畸形。
分析了15个先前浸软的胎儿额骨和蝶骨，并使用微型CT获得的三维重建图像测量了视神经管直径以及眼眶从前上颌缝到额颧缝的距离。
300毫米胎儿的视神经管平均直径测量为1546±36微米，400毫米胎儿为2470±123微米，500毫米胎儿为3757±203微米。这一趋势表明胎儿期视神经管呈线性增大。在同一时期，眼眶直径从300毫米胎儿的12319±559微米增大到500毫米胎儿的19788±736微米。与视神经管数据中的相同曲线相比，生长曲线明显更低。我们还计算了这些组之间眼眶直径与视神经管直径的比值，该比值从300毫米胎儿的7.9±0.4降至500毫米胎儿的5.3±0.2。
胎儿早期和晚期视神经管与眼眶腔的发育动态不同。这些结构的直径与胎儿长度的相关性更好。
