作为卵母细胞成熟候选“启动因子”的原癌基因mos的产物。

The product of the mos proto-oncogene as a candidate "initiator" for oocyte maturation.

作者信息

Sagata N, Daar I, Oskarsson M, Showalter S D, Vande Woude G F

机构信息

BRI-Basic Research Program, National Cancer Institute, Frederick Cancer Research Facility, MD 21701.

出版信息

Science. 1989 Aug 11;245(4918):643-6. doi: 10.1126/science.2474853.

DOI:10.1126/science.2474853

PMID:2474853

Abstract

The endogenous c-mos product, pp39mos, is required for progesterone-induced meiotic maturation in Xenopus oocytes. Treatment of oocytes with progesterone induced a rapid increase in pp39mos that preceded both the activation of maturation promoting factor (MPF) and germinal vesicle breakdown (GVBD). Microinjection of synthetic mos RNA into oocytes activated MPF and induced GVBD in the absence of progesterone. Thus, the mos proto-oncogene product may qualify as a candidate "initiator" protein of MPF and is at least one of the "triggers" for G2 to M transition.

摘要

非洲爪蟾卵母细胞中孕酮诱导的减数分裂成熟需要内源性c-mos产物pp39mos。用孕酮处理卵母细胞会导致pp39mos迅速增加，这发生在成熟促进因子（MPF）激活和生发泡破裂（GVBD）之前。在没有孕酮的情况下，将合成的mos RNA显微注射到卵母细胞中可激活MPF并诱导GVBD。因此，mos原癌基因产物可能符合作为MPF候选“启动子”蛋白的条件，并且至少是G2期到M期转换的“触发因素”之一。