紫穗槐对砷诱导的大鼠肾毒性的改善作用
Ameliorative Effect of Tephrosia Purpurea in Arsenic-induced Nephrotoxicity in Rats.
作者信息
Gora Ravuri Halley, Kerketta Priscilla, Baxla Sushma Lalita, Toppo Reetu, Prasad Raju, Patra Pabitra Hriday, Roy Birendra Kumar
机构信息
Department of Veterinary Pharmacology and Toxicology, Ranchi Veterinary College, Birsa Agricultural University, India.
Department of Veterinary Public Health, I.V.R.I. Izatnagar, Bareilly, India.
出版信息
Toxicol Int. 2014 Jan;21(1):78-83. doi: 10.4103/0971-6580.128807.
OBJECTIVES
The present investigation was conducted to evaluate the nephroprotective activity of Tephrosia purpurea (TPE) against arsenic-induced toxicity.
MATERIALS AND METHODS
Twenty four number of wistar rats were equally divided into three groups. Sodium arsenite (10 mg/kg) was orally given to group I for 28 days, additionally group II was orally treated with TPE (500 mg/kg), while the control group was kept untreated with neither arsenic nor TPE. Serum biomarker levels, oxidative stress indices and arsenic concentration in kidney were estimated. Histopathology of kidney was also conducted.
RESULTS
Group II animals show significantly reduced blood urea nitrogen and plasma creatinine, and increased serum albumin level compared to group I. The higher lipid peroxidation with exhausted superoxide dismutase activity and reduced glutathione level were noticed in group I compared to group II. There was no significant difference in arsenic accumulation in kidneys between the two arsenic treated groups, but the histopathology of kidney of group II rats revealed reduced necrosis and intact tubular architecture as compared to group I.
CONCLUSIONS
Tephrosia Purpurea extract has a significant role in protecting the animals from arsenic-induced nephrotoxicity.
目的
进行本研究以评估紫穗槐（TPE）对砷诱导的毒性的肾保护活性。
材料与方法
将24只Wistar大鼠平均分为三组。第一组口服亚砷酸钠（10mg/kg），持续28天，此外，第二组口服TPE（500mg/kg），而对照组既不给予砷也不给予TPE。测定血清生物标志物水平、氧化应激指标和肾脏中的砷浓度。还进行了肾脏组织病理学检查。
结果
与第一组相比，第二组动物的血尿素氮和血浆肌酐显著降低，血清白蛋白水平升高。与第二组相比，第一组脂质过氧化程度更高，超氧化物歧化酶活性耗尽，谷胱甘肽水平降低。两个砷处理组肾脏中的砷积累没有显著差异，但与第一组相比，第二组大鼠肾脏的组织病理学显示坏死减少，肾小管结构完整。
结论
紫穗槐提取物在保护动物免受砷诱导的肾毒性方面具有重要作用。
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