Schlegel P N, Brendler C B
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Urology. 1989 Aug;34(2):69-72. doi: 10.1016/0090-4295(89)90165-9.
A common affliction of older men is bladder outlet obstruction secondary to benign prostatic hyperplasia for which the standard treatment is surgical prostatectomy. We report on six men with urinary retention from benign prostatic hyperplasia who were not medically able to undergo surgical prostatectomy but were successfully treated with the luteinizing hormone-releasing hormone (LH-RH) agonist, leuprolide acetate. This therapy is exemplified by the case of a sixty-six-year-old man with hemophilia B and urinary retention. The patient was treated with daily subcutaneous injections of 1 mg of leuprolide acetate, and prostatic size decreased from 132 g to 42 g, with initiation of spontaneous micturition while on treatment. For patients with symptomatic benign prostatic hyperplasia who are not candidates for surgery, treatment with an LH-RH agonist, such as leuprolide acetate, should be considered as a possible alternative.
老年男性的一种常见疾病是继发于良性前列腺增生的膀胱出口梗阻，其标准治疗方法是手术前列腺切除术。我们报告了6例因良性前列腺增生导致尿潴留的男性患者，他们因身体原因无法接受手术前列腺切除术，但通过使用促黄体生成素释放激素（LH-RH）激动剂醋酸亮丙瑞林成功得到治疗。一名患有乙型血友病和尿潴留的66岁男性患者的病例就是这种治疗方法的例证。该患者每天接受1毫克醋酸亮丙瑞林的皮下注射治疗，前列腺体积从132克减小到42克，并且在治疗期间开始自主排尿。对于有症状的良性前列腺增生且不适合手术的患者，应考虑使用LH-RH激动剂（如醋酸亮丙瑞林）进行治疗，作为一种可能的替代方案。
