Yamaguchi Masayoshi
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Biomed Rep. 2014 May;2(3):303-308. doi: 10.3892/br.2014.245. Epub 2014 Mar 5.
Regucalcin was first identified in 1978 as a regulatory protein of Ca signaling in liver cells. Regucalcin was shown to play a multifunctional role in cell regulation, such as maintainance of intracellular Ca homeostasis and suppression of signal transduction, protein synthesis, nuclear function, cell proliferation and apoptosis in various types of cells and tissues. Cardiac excitation-contraction coupling is based on the regulation of intracellular Ca concentration by the Ca pump in the sarcoplasmic reticulum of heart muscle cells. Regucalcin, which is expressed in the heart, was found to increase rat heart sarcoplasmic reticulum Ca-ATPase activity and ATP-dependent Ca uptake and mitochondrial Ca-ATPase activity. Regucalcin was also shown to suppress Ca-dependent protein tyrosine phosphatase, Ca/calmodulin-dependent protein phosphatase (calcineurin) and nitric oxide (NO) synthase activity in the heart cytoplasm. Moreover, regucalcin was found to activate superoxide dismutase (SOD), which plays a significant role in the prevention of cell death and apoptosis in the heart. Regucalcin may be a key molecule in heart muscle cell regulation through Ca signaling. Regucalcin may also play a pathophysiological role in heart failure. The aim of this study was to review the recent findings regarding the role of regucalcin in Ca signaling in the heart.
调节钙素于1978年首次被鉴定为肝细胞中钙信号的调节蛋白。调节钙素在细胞调节中发挥多种功能作用，如维持细胞内钙稳态以及抑制各种类型细胞和组织中的信号转导、蛋白质合成、核功能、细胞增殖和凋亡。心脏兴奋 - 收缩偶联基于心肌细胞肌浆网中钙泵对细胞内钙浓度的调节。在心脏中表达的调节钙素被发现可增加大鼠心脏肌浆网钙 - ATP酶活性、ATP依赖的钙摄取以及线粒体钙 - ATP酶活性。调节钙素还被证明可抑制心脏细胞质中钙依赖性蛋白酪氨酸磷酸酶、钙/钙调蛋白依赖性蛋白磷酸酶（钙调神经磷酸酶）和一氧化氮（NO）合酶活性。此外，发现调节钙素可激活超氧化物歧化酶（SOD），其在预防心脏细胞死亡和凋亡中起重要作用。调节钙素可能是通过钙信号调节心肌细胞的关键分子。调节钙素在心力衰竭中也可能发挥病理生理作用。本研究的目的是综述关于调节钙素在心脏钙信号中作用的最新研究结果。
