细胞因子诱导的杀伤细胞培养中靶向调节性T细胞（综述）
Targeting regulatory T cells in cytokine-induced killer cell cultures (Review).
作者信息
Tao Qianshan, Wang Huiping, Zhai Zhimin
机构信息
Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China.
出版信息
Biomed Rep. 2014 May;2(3):317-320. doi: 10.3892/br.2014.234. Epub 2014 Feb 7.
Abstract
Regulatory T cells (Tregs) are potent immunosuppressive cells that promote tumor growth and invasion by inducing immune escape and suppressing the antitumor immune response. Cytokine-induced killer (CIK) cells are considered to be the primary candidate for adoptive immunotherapy due to their strong antitumor activity. It was recently reported that the concomitant presence of Tregs may decrease the cytotoxicity of CIK cells. Therefore, depletion or downregulation of Tregs in CIK cell cultures by optimizing the culture program may enhance CIK cell cytotoxicity and . The aim of the present review was to summarize the currently available studies on the optimal culture strategy for improving the antitumor activity of CIK cells through targeting Tregs.
摘要
调节性T细胞（Tregs）是强大的免疫抑制细胞，可通过诱导免疫逃逸和抑制抗肿瘤免疫反应来促进肿瘤生长和侵袭。细胞因子诱导的杀伤（CIK）细胞因其强大的抗肿瘤活性而被认为是过继性免疫治疗的主要候选者。最近有报道称，Tregs的同时存在可能会降低CIK细胞的细胞毒性。因此，通过优化培养方案在CIK细胞培养中去除或下调Tregs可能会增强CIK细胞的细胞毒性。本综述的目的是总结目前关于通过靶向Tregs提高CIK细胞抗肿瘤活性的最佳培养策略的研究。
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